Glossary

Peptide terms, in plain English

Every acronym and bit of jargon you'll run into, reconstitution, COA, IGF-1, titration, and the rest, explained clearly.

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What is a peptide, and how does it work?

A peptide is a short chain of amino acids, the same building blocks that make up proteins, just far smaller. Your body already makes thousands of them. They're its messenger molecules: tiny signals that travel to your cells and tell them what to do.

How they work: each peptide has a shape that fits a specific receptor on a cell, like a key fitting one lock. When it docks, it delivers an instruction: repair this tissue, release growth hormone, calm this inflammation, curb appetite. A peptide doesn't force anything, it nudges a process your body can already do, just more precisely. Different peptides carry different messages, which is why BPC-157 (healing) does something completely different from a GLP-1 like semaglutide (appetite and blood sugar).

Therapeutic peptides, the ones people run in protocols, copy or amplify those natural signals. They come as a freeze-dried powder, get mixed with sterile water (“reconstitution”), and are usually injected in tiny microgram doses. The terms below cover every step of that process.

Bacteriostatic waterBAC water
Sterile water containing 0.9% benzyl alcohol, which prevents bacterial growth so a reconstituted vial stays usable for ~28 days refrigerated. Use this, not plain sterile water, for multi-dose vials.
Certificate of AnalysisCOA
A lab document showing a batch's purity and identity. The single most important tool for verifying you got what you paid for.
Concentration
How much peptide is in each mL of solution (mcg/mL), set by the vial size and how much water you add. Determines how many units = your dose.
Cycle
A defined on-period of use (e.g., 8-12 weeks) often followed by a break, to maintain sensitivity and limit risk.
Endotoxin
Bacterial toxin measured in EU/mg. For anything injected, a COA should report endotoxin below 1 EU/mg.
GH secretagogue
Any compound that stimulates growth-hormone release (GHRHs, GHRPs, and oral MK-677).
GHRH
Growth-Hormone-Releasing Hormone. Analogues like CJC-1295, sermorelin, and tesamorelin prompt the body's own GH release.
GHRP
Growth-Hormone-Releasing Peptide (e.g., Ipamorelin, GHRP-2/6). Works through the ghrelin receptor; often stacked with a GHRH.
GIP
Glucose-dependent Insulinotropic Polypeptide, a second incretin hormone. Tirzepatide activates both GLP-1 and GIP receptors.
GLP-1
Glucagon-Like Peptide-1, a gut hormone that reduces appetite and improves blood sugar. GLP-1 agonists (semaglutide, etc.) are the basis of modern weight-loss medicine.
Half-life
How long it takes for half a dose to clear the body. It drives how often you dose, short half-life means more frequent injections.
HPLC
High-Performance Liquid Chromatography, the standard test for peptide purity. A good COA shows the HPLC chromatogram, not just a percentage.
IGF-1
Insulin-like Growth Factor 1, the downstream marker of GH activity. The key lab to confirm a GH peptide is working (and to catch excess).
Insulin syringe (U-100)
A fine syringe marked 0-100 units (1 mL). Standard for subcutaneous peptide dosing.
IntramuscularIM
An injection into muscle tissue, using a longer needle. Used for some peptides and certain preparations.
Intranasal
Administration as a nasal spray, absorbed through the nasal mucosa. Common for Semax, Selank, and some others.
Lipohypertrophy
Lumpy fat-tissue changes from repeatedly injecting the same spot. Prevented by rotating injection sites.
Loading dose
A higher initial dose (or frequency) at the start of a protocol, common with TB-500, before dropping to maintenance.
Lyophilized
Freeze-dried. Peptides are shipped as a lyophilized powder for stability and reconstituted before use.
Mass spectrometry
A lab test that confirms a vial actually contains the peptide it claims (its identity/molecular weight). Purity is meaningless if the molecule is wrong.
Peptide
A short chain of amino acids, smaller than a protein, that acts as a signaling molecule in the body. Therapeutic peptides mimic or modulate these natural signals.
Reconstitution
Mixing freeze-dried (lyophilized) peptide powder with a liquid (usually bacteriostatic water) to make an injectable or usable solution.
Research use onlyRUO
A label meaning a compound has not been evaluated by the FDA for human use. Most research peptides are sold this way.
Stack
Using two or more peptides together for complementary effects (e.g., BPC-157 + TB-500 for healing).
SubcutaneousSubQ
An injection into the fatty layer just under the skin (e.g., abdomen, thigh). The most common route for most peptides.
Titration
Gradually increasing a dose over time to let the body adjust, essential for GLP-1s to manage nausea.
Units / IU
The markings on an insulin (U-100) syringe. 100 units = 1 mL. Dose calculators convert your mcg dose into the units to draw.