Vasoactive Intestinal Peptide — researched for chronic inflammatory response (CIRS) and immune balance.
VIP (Vasoactive Intestinal Peptide) is a natural signaling molecule found throughout the body — in the gut, lungs, brain and immune system — where it acts as a powerful anti-inflammatory and regulator of immune balance, blood vessels and circadian rhythm.
In the peptide community it is best known from the Shoemaker protocol for Chronic Inflammatory Response Syndrome (CIRS), typically from mold/biotoxin exposure, where intranasal VIP is used near the end of treatment to help restore normal regulation after the underlying exposure has been removed.
Because it dilates blood vessels, it can lower blood pressure and cause flushing. It is generally used only after addressing the root environmental cause, not as a standalone fix.
Used to help restore immune and hormonal regulation in CIRS protocols.
Used clinically within the Shoemaker protocol; limited independent trials
Broad anti-inflammatory and vasoregulatory effects.
Well-characterized physiology; therapeutic use is niche
Studied for pulmonary inflammation and pressure.
Research interest; not established therapy
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Mostly preclinical (animal/in-vitro) evidence with a clear mechanism. Human effects are largely anecdotal.
Men in structured CIRS recovery after environmental/mold exposure is resolved
Typically used late in a CIRS protocol, not standalone. Can lower blood pressure and cause flushing.
Women in CIRS protocols or seeking immune/inflammatory regulation
Limited female-specific data. Watch for blood-pressure drops. Use under guidance; avoid in pregnancy.
Often used in CIRS protocols; limited female-specific data.
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Can lower blood pressure — caution if hypotensive.
Typically used only after addressing environmental/mold exposure.
May cause flushing or a transient blood-pressure drop.
Standardized data for VIP is limited. These are the general effects to watch for with this type of compound.
Rotate sites, use sterile technique, let alcohol dry before injecting.
Hydrate and ease the dose; usually transient as your body adjusts.
Individual responses vary. Stop and consult a clinician for severe, persistent, or unexpected reactions.
10 steps with photos, pro tips, and a dosing calculator.
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View Full GuidePepCompass provides educational information only. Nothing on this platform constitutes medical advice, diagnosis, or treatment. All content is for informational and research purposes only. Always consult a licensed healthcare provider before starting any peptide protocol. Individual results vary.