Essential cellular coenzyme used to support energy metabolism, DNA repair, and healthy aging.
NAD+ (nicotinamide adenine dinucleotide) is not a peptide but an essential coenzyme present in every cell, where it powers energy metabolism and fuels the sirtuins and PARPs — enzymes central to DNA repair and healthy aging. NAD+ levels fall substantially with age.
The longevity rationale is straightforward: restore a molecule that declines with age and underpins mitochondrial energy and cellular repair. Injectable NAD+ (subcutaneous or IV) aims to raise levels more directly than oral precursors like NMN or NR.
The science of energy metabolism and DNA repair is solid; the open question is how much exogenous NAD+ translates into long-term healthspan benefit. The main practical issue is comfort — infused too fast it causes flushing, nausea and chest tightness, so it is given slowly.
Fuels cellular energy production.
NAD+ biology is well established; energy effects are mechanistically clear
Substrate for sirtuins/PARPs involved in repair and longevity.
Strong basic science; long-term human outcome data still developing
Used for mental clarity, recovery and addiction-recovery protocols.
Popular clinically (IV drips); human outcome evidence is mixed
We rate every peptide honestly across four dimensions — and tell you what it's not.
Promising but early. Strong animal data and/or small/preliminary human studies, not yet confirmed in robust trials.
Men focused on energy, longevity and recovery willing to dose slowly
Go slow — rapid administration causes flushing, nausea and chest tightness. Subcutaneous and IV differ greatly in comfort and dose.
Women seeking energy, clarity and healthy-aging support
Well tolerated when dosed slowly; no hormonal interactions reported. Avoid in pregnancy without guidance.
Well tolerated; no hormonal interactions. Avoid in pregnancy without guidance.
This section is always free and never locked.
Rapid administration causes flushing, nausea, and chest tightness — go slow.
Subcutaneous and IV routes differ widely in dose and comfort.
Standardized data for NAD+ is limited. These are the general effects to watch for with this type of compound.
Rotate sites, use sterile technique, let alcohol dry before injecting.
Hydrate and ease the dose; usually transient as your body adjusts.
Individual responses vary. Stop and consult a clinician for severe, persistent, or unexpected reactions.
14 steps with photos, pro tips, and a dosing calculator.
Unlock Full Guide7 days free. Then $24/month.
████████ ████
████████ ████
████████ ████
Dosing info requires Core or Pro
Unlock DosingAlways free. Never locked.
A preview of the member outcomes dashboard. Real, anonymized NAD+ results populate here as the community logs data.
See aggregated results from real users — benefit ratings, common goals, side effect frequency, and more.
Unlock with Core or ProGet the complete step-by-step guide, personalized dosing, and daily tracking.
View Full GuidePepCompass provides educational information only. Nothing on this platform constitutes medical advice, diagnosis, or treatment. All content is for informational and research purposes only. Always consult a licensed healthcare provider before starting any peptide protocol. Individual results vary.