Mitochondrial-derived peptide studied for cytoprotection, metabolic health, and longevity signaling.
Humanin is a small mitochondrial-derived peptide — one of the first discovered — that acts as a cytoprotective signaling molecule, helping cells survive stress. It was originally found in the brain region spared in Alzheimer's disease, which hinted at a protective role.
Research links humanin to protection of neurons and other cells, improved insulin sensitivity and metabolic health, and broad longevity signaling. Levels tend to fall with age, paralleling other mitochondrial-derived peptides like MOTS-c.
The evidence is mostly preclinical, with human data still early. It is used conservatively, usually a few times weekly, by people pursuing longevity and metabolic goals.
Helps cells resist stress and survive damaging conditions.
Well-characterized preclinically; human data early
Supports insulin sensitivity and metabolic function.
Preclinical and early human interest
Part of the mitochondrial peptide network tied to aging.
Mechanistically interesting; not yet human-validated at scale
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Mostly preclinical (animal/in-vitro) evidence with a clear mechanism. Human effects are largely anecdotal.
Longevity- and metabolism-focused men exploring mitochondrial peptides
Mostly preclinical evidence — cycle conservatively. Pairs with other mitochondrial peptides.
Women interested in metabolic and longevity support
No hormonal interactions reported; limited female data. Avoid in pregnancy.
Limited female-specific data; no hormonal interactions known.
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Primarily preclinical evidence — human data is early.
Cycle conservatively.
Standardized data for Humanin is limited. These are the general effects to watch for with this type of compound.
Rotate sites, use sterile technique, let alcohol dry before injecting.
Hydrate and ease the dose; usually transient as your body adjusts.
Individual responses vary. Stop and consult a clinician for severe, persistent, or unexpected reactions.
14 steps with photos, pro tips, and a dosing calculator.
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A preview of the member outcomes dashboard. Real, anonymized Humanin results populate here as the community logs data.
See aggregated results from real users — benefit ratings, common goals, side effect frequency, and more.
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View Full GuidePepCompass provides educational information only. Nothing on this platform constitutes medical advice, diagnosis, or treatment. All content is for informational and research purposes only. Always consult a licensed healthcare provider before starting any peptide protocol. Individual results vary.